Cancer mortality among aircraft manufacturing workers: an extended follow-up.

Lipworth L, Sonderman JS, Mumma MT, Tarone RE, Marano DE, Boice JD, McLaughlin JK
J Occup Environ Med. 2011 53 (9): 992-1007

PMID: 21866047 · DOI:10.1097/JOM.0b013e31822e0940

OBJECTIVE - Extended cancer follow-up among 77,943 aircraft workers.

METHODS - Comprehensive exposure information enabled detailed classification of trichloroethylene (TCE), perchloroethylene (PCE), mixed solvents, and chromates exposure among these workers.

RESULTS - Exposure to TCE, PCE, mixed solvents or chromates was not associated with increased cancer risk overall or for most cancer sites. Elevated rates compared with the general population were seen for non-Hodgkin lymphoma for PCE exposure, and colon and testicular cancers and multiple myeloma for mixed solvents exposure. Internal cohort analyses, however, showed no significant trends of increasing risk for these cancers with increasing years of exposure to TCE, PCE or mixed solvents.

CONCLUSION - This large, long-term cohort study with comprehensive exposure assessment found no consistent evidence of increased cancer risk overall or by site among aircraft workers, including those with long-term exposure to TCE, PCE, and mixed solvents.

(C)2011The American College of Occupational and Environmental Medicine

MeSH Terms (13)

Aircraft California Chromates Cohort Studies Female Humans Male Neoplasms Occupational Diseases Occupational Exposure Solvents Tetrachloroethylene Trichloroethylene

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