Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.

Revenko AS, Gao D, Crosby JR, Bhattacharjee G, Zhao C, May C, Gailani D, Monia BP, MacLeod AR
Blood. 2011 118 (19): 5302-11

PMID: 21821705 · PMCID: PMC4425441 · DOI:10.1182/blood-2011-05-355248

MeSH Terms (16)

Animals Disease Models, Animal Factor XII Factor XII Deficiency Gene Knockdown Techniques Hemorrhage Hemostasis Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Oligonucleotides, Antisense Prekallikrein Risk Factors RNA, Messenger Thrombosis

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