Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.

Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP
J Biol Chem. 2011 286 (38): 33021-8

PMID: 21813643 · PMCID: PMC3190903 · DOI:10.1074/jbc.M111.282434

MeSH Terms (13)

Biocatalysis Cholesterol Cholesterol 7-alpha-Hydroxylase Chromatography, Liquid Cytochrome P-450 Enzyme System Dehydrocholesterols Epoxy Compounds Humans Ketocholesterols Mass Spectrometry Microsomes, Liver Oxidation-Reduction Recombinant Proteins

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