A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

Mussolino C, Morbitzer R, Lütge F, Dannemann N, Lahaye T, Cathomen T
Nucleic Acids Res. 2011 39 (21): 9283-93

PMID: 21813459 · PMCID: PMC3241638 · DOI:10.1093/nar/gkr597

MeSH Terms (13)

Bacterial Proteins Deoxyribonucleases DNA-Binding Proteins DNA Cleavage Gene Targeting Genetic Engineering Genome, Human HEK293 Cells Humans Protein Engineering Protein Structure, Tertiary Trans-Activators Transcription Activator-Like Effectors

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