Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.

Miller M, Shi J, Zhu Y, Kustov M, Tian JB, Stevens A, Wu M, Xu J, Long S, Yang P, Zholos AV, Salovich JM, Weaver CD, Hopkins CR, Lindsley CW, McManus O, Li M, Zhu MX
J Biol Chem. 2011 286 (38): 33436-46

PMID: 21795696 · PMCID: PMC3190871 · DOI:10.1074/jbc.M111.274167

MeSH Terms (19)

Animals Cations Female Fluorescent Dyes HEK293 Cells High-Throughput Screening Assays Humans Indoles Intestines Ion Channel Gating Male Mice Mice, Inbred C57BL Myocytes, Smooth Muscle Piperidines Receptors, Muscarinic Receptors, Opioid, mu Structure-Activity Relationship TRPC Cation Channels

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