Defining genome maintenance pathways using functional genomic approaches.

Bansbach CE, Cortez D
Crit Rev Biochem Mol Biol. 2011 46 (4): 327-41

PMID: 21787120 · PMCID: PMC3144553 · DOI:10.3109/10409238.2011.588938

Genome maintenance activities including DNA repair, cell division cycle control, and checkpoint signaling pathways preserve genome integrity and prevent disease. Defects in these pathways cause birth defects, neurodegeneration, premature aging, and cancer. Recent technical advances in functional genomic approaches such as expression profiling, proteomics, and RNA interference (RNAi) technologies have rapidly expanded our knowledge of the proteins that work in these pathways. In this review, we examine the use of these high-throughput methodologies in higher eukaryotic organisms for the interrogation of genome maintenance activities.

MeSH Terms (18)

Animals Cell Cycle Proteins Chromatin DNA-Binding Proteins DNA Damage DNA Repair DNA Replication Gene Expression Profiling Genome, Human Humans Mass Spectrometry Protein Array Analysis Protein Interaction Mapping Protein Processing, Post-Translational Proteomics RNA Interference Signal Transduction Two-Hybrid System Techniques

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