Moxifloxacin prophylaxis for chemoembolization or embolization in patients with previous biliary interventions: a pilot study.

Khan W, Sullivan KL, McCann JW, Gonsalves CF, Sato T, Eschelman DJ, Brown DB
AJR Am J Roentgenol. 2011 197 (2): W343-5

PMID: 21785063 · DOI:10.2214/AJR.10.6019

OBJECTIVE - Abscess formation is a common serious adverse event after intraarterial therapy for hepatic malignancy in patients with colonized bile ducts. The combination of antibiotic prophylaxis and bowel preparation has been used to prevent hepatic abscess. We describe our outcomes with moxifloxacin prophylaxis alone without bowel preparation.

CONCLUSION - Ten patients underwent 25 procedures and were followed for a median of 250 days. No abscesses developed. Our results suggest moxifloxacin alone may suffice for prophylaxis.

MeSH Terms (21)

Anti-Infective Agents Antibiotic Prophylaxis Antineoplastic Agents Aza Compounds Biliary Tract Diseases Case-Control Studies Chemoembolization, Therapeutic Embolization, Therapeutic Ethiodized Oil Female Fluoroquinolones Humans Liver Abscess Liver Neoplasms Male Moxifloxacin Pilot Projects Quinolines Radiography, Interventional Retrospective Studies Risk Factors

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