Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

Bychkov ER, Ahmed MR, Gurevich VV, Benovic JL, Gurevich EV
Neurobiol Dis. 2011 44 (2): 248-58

PMID: 21784156 · PMCID: PMC3166984 · DOI:10.1016/j.nbd.2011.07.009

Alterations of multiple G protein-mediated signaling pathways are detected in schizophrenia. G protein-coupled receptor kinases (GRKs) and arrestins terminate signaling by G protein-coupled receptors exerting a powerful influence on receptor functions. Modifications of arrestin and/or GRKs expression may contribute to schizophrenia pathology. Cortical expression of arrestins and GRKs was measured postmortem in control and subjects with schizophrenia or schizoaffective disorder. Additionally, arrestin/GRK expression was determined in elderly patients with schizophrenia and age-matched control. Patients with schizophrenia, but not schizoaffective disorder, displayed a reduced concentration of arrestin and GRK mRNAs and GRK3 protein. Arrestins and GRK significantly decreased with age. In elderly patients, GRK6 was reduced, with other GRKs and arrestins unchanged. A reduced cortical concentration of GRKs in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia. The data suggest distinct molecular mechanisms underlying schizophrenia and schizoaffective disorder.

Copyright © 2011. Published by Elsevier Inc.

MeSH Terms (17)

Adult Aged Aged, 80 and over Arrestins Cohort Studies Female G-Protein-Coupled Receptor Kinase 2 G-Protein-Coupled Receptor Kinase 3 G-Protein-Coupled Receptor Kinase 5 G-Protein-Coupled Receptor Kinases Humans Male Middle Aged Prefrontal Cortex Psychotic Disorders Schizophrenia Young Adult

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