Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer.

Yang X, Turke AB, Qi J, Song Y, Rexer BN, Miller TW, Jänne PA, Arteaga CL, Cantley LC, Engelman JA, Asara JM
Cancer Res. 2011 71 (18): 5965-75

PMID: 21775521 · PMCID: PMC3209668 · DOI:10.1158/0008-5472.CAN-11-0445

MeSH Terms (20)

Animals Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Chromatography, Liquid Class Ia Phosphatidylinositol 3-Kinase Class I Phosphatidylinositol 3-Kinases Enzyme Activation Humans Lung Neoplasms Mice Mice, Nude Mutation Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Receptor Protein-Tyrosine Kinases RNA, Small Interfering Sirolimus Tandem Mass Spectrometry Transcription Factors Transfection

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