Aggressive sinonasal natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis.

Turner JH, Loyo M, Lin SY
Am J Otolaryngol. 2012 33 (1): 188-91

PMID: 21764176 · DOI:10.1016/j.amjoto.2011.05.003

Extranodal natural killer/T-cell lymphoma of the nasal cavity is a rare malignancy with poor overall prognosis. We report the case of a rapidly fatal natural killer/T-cell lymphoma of the nasal cavity complicated by the concominant development of hemophagocytic lymphohistiocytosis. This disorder is marked by clinical findings such as fever and splenomegaly, a multitude of abnormal laboratory findings, and a profound proliferation of circulating macrophages. Left untreated, multi-organ failure and death are common. Prompt diagnosis is essential to the successful management of this disorder and for subsequent recovery.

Copyright © 2012 Elsevier Inc. All rights reserved.

MeSH Terms (10)

Diagnosis, Differential Endoscopy Fatal Outcome Humans Lymphohistiocytosis, Hemophagocytic Lymphoma, T-Cell Male Natural Killer T-Cells Nose Neoplasms Young Adult

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