The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.

Wilson AJ, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, Schreiber SL, Khabele D
Cancer Biol Ther. 2011 12 (6): 484-93

PMID: 21738006 · PMCID: PMC3218590 · DOI:10.4161/cbt.12.6.15956

MeSH Terms (20)

Antineoplastic Agents Apoptosis Caspase 3 Cell Line, Tumor Cell Nucleus Cell Survival Cisplatin DNA Damage Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Drug Synergism Female Histone Deacetylase Inhibitors Histones Humans Microscopy, Fluorescence Ovarian Neoplasms Phosphorylation Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases

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