The effect of adjunctive armodafinil on cognitive performance and psychopathology in antipsychotic-treated patients with schizophrenia/schizoaffective disorder: a randomized, double-blind, placebo-controlled trial.

Bobo WV, Woodward ND, Sim MY, Jayathilake K, Meltzer HY
Schizophr Res. 2011 130 (1-3): 106-13

PMID: 21641776 · DOI:10.1016/j.schres.2011.05.015

BACKGROUND - The efficacy, safety and tolerability of adjunctive armodafinil for cognitive performance, and negative and affective symptoms, were examined in 60 patients with schizophrenia or schizoaffective disorder.

METHOD - This was a 6-week, double-blind, placebo-controlled, fixed dose trial of armodafinil (150 mg/d) augmentation in patients with clinically stable schizophrenia or schizoaffective disorder. Cognition, psychopathology, alertness/wakefulness and adverse effects were assessed with standardized rating instruments. The primary endpoint was performance on measures of attention/vigilance.

RESULTS - Patients were randomly allocated to adjunctive armodafinil or placebo. There was a significant Drug×Time interaction effect for attention/vigilance, due to modest non-significant worsening in the armodafinil group and improvement in the armodafinil group [CPT-Pairs d', F(1,40)=6.2, p=0.017]. However, it became non-significant after correction for multiple comparisons. There were no differences between armodafinil and placebo in other cognitive domains or psychopathology measures. However, armodafinil was associated with significant improvement in the Scale for the Assessment of Negative Symptoms (SANS) anhedonia-asociality [F(1,41)=4.1, p=0.05].

CONCLUSIONS - There were no significant differences in neurocognitive measures between adjunctive armodafinil and placebo in this 6-week study. Armodafinil improved anhedonia-asociality, but not other negative symptom domains.

Copyright © 2011 Elsevier B.V. All rights reserved.

MeSH Terms (20)

Adolescent Adult Antipsychotic Agents Benzhydryl Compounds Cognition Disorders Double-Blind Method Factor Analysis, Statistical Female Humans Male Middle Aged Modafinil Neuropsychological Tests Psychiatric Status Rating Scales Psychopathology Psychotic Disorders Retrospective Studies Schizophrenia Treatment Outcome Young Adult

Connections (1)

This publication is referenced by other Labnodes entities:

Links