Epithelial organization: new perspective on α-catenin from an ancient source.

Reynolds AB
Curr Biol. 2011 21 (11): R430-2

PMID: 21640901 · DOI:10.1016/j.cub.2011.04.043

Cadherins and catenins evidently partnered at the dawn of the animal kingdom to enable the first polarized epithelium, and perhaps animal evolution itself. New evidence from a primitive slime mold, however, suggests that α- and β-catenins may have engaged this function independently, long before cadherins arrived on the scene.

Copyright © 2011 Elsevier Ltd. All rights reserved.

MeSH Terms (8)

alpha Catenin beta Catenin Cadherins Cell Polarity Dictyostelium Epithelial Cells Intercellular Junctions Protozoan Proteins

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