Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK.

Spurlock CF, Aune ZT, Tossberg JT, Collins PL, Aune JP, Huston JW, Crooke PS, Olsen NJ, Aune TM
Arthritis Rheum. 2011 63 (9): 2606-16

PMID: 21618198 · PMCID: PMC3165146 · DOI:10.1002/art.30457

MeSH Terms (13)

Adult Antirheumatic Agents Apoptosis Arthritis, Rheumatoid Biopterin Cell Line, Tumor Gene Expression Humans JNK Mitogen-Activated Protein Kinases Methotrexate Middle Aged Reactive Oxygen Species Tumor Cells, Cultured

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