Asthma is a distinct comorbid condition in children with sickle cell anemia with elevated total and allergen-specific IgE levels.

Ross JG, Bernaudin F, Strunk RC, Kamdem A, Arnaud C, Hervé M, Delacourt C, DeBaun MR
J Pediatr Hematol Oncol. 2011 33 (5): e205-8

PMID: 21617566 · PMCID: PMC3120905 · DOI:10.1097/MPH.0b013e31820db7b1

Asthma in children with sickle cell anemia (SCA) is associated with increased morbidity and mortality. However, the definition of asthma in SCA is based on a physician's impression. In a retrospective cohort of children with SCA, relationships between a physician diagnosis of asthma and total and allergen-specific immunoglobulin E levels were evaluated. In children with SCA, elevated total and specific immunoglobulin E levels were significantly associated with a diagnosis of asthma (P<0.05), further supporting the concept that asthma is a separate comorbid condition of SCA.

MeSH Terms (14)

Allergens Anemia, Sickle Cell Asthma Child, Preschool Cohort Studies Comorbidity Epitopes Female Humans Immunoglobulin E Infant Male Retrospective Studies Risk Factors

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