Laparoscopic nephron-sparing resection of synchronous Wilms tumors in a case of hyperplastic perilobar nephroblastomatosis.

Rauth TP, Slone J, Crane G, Correa H, Friedman DL, Lovvorn HN
J Pediatr Surg. 2011 46 (5): 983-8

PMID: 21616266 · PMCID: PMC3105348 · DOI:10.1016/j.jpedsurg.2011.01.025

Diffuse hyperplastic perilobar nephroblastomatosis (DHPLN) is a rare precursor lesion of Wilms tumor (WT). Because of the increased risk to develop WT in either kidney, current management algorithms of DHPLN merit nephron-sparing strategies, beginning with chemotherapy and close radiographic monitoring into late childhood. After resolution of DHPLN, subsequent detection of a renal nodule mandates resection to exclude WT. Here, we report the case of a 4-year-old girl who developed 2 synchronous nodules in the right kidney more than 2 years after completion of therapy for DHPLN. Because of the early detection and peripheral location of these 2 nodules, laparoscopic nephron-sparing resection of each was performed using ultrasonic dissection. Both nodules were determined on pathology to be favorable histology WT with negative surgical margins. The child was placed on vincristine and actinomycin D therapy for 18 weeks.

Copyright © 2011 Elsevier Inc. All rights reserved.

MeSH Terms (19)

Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Dactinomycin Disease Progression Doxorubicin Female Follow-Up Studies Humans Hyperplasia Infant Kidney Diseases Kidney Neoplasms Laparoscopy Magnetic Resonance Imaging Neoplasms, Multiple Primary Nephrons Precancerous Conditions Vincristine Wilms Tumor

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