How do control-based approaches enter into biology?

LeDuc PR, Messner WC, Wikswo JP
Annu Rev Biomed Eng. 2011 13: 369-96

PMID: 21599491 · DOI:10.1146/annurev-bioeng-071910-124651

Control is intrinsic to biological organisms, whose cells are in a constant state of sensing and response to numerous external and self-generated stimuli. Diverse means are used to study the complexity through control-based approaches in these cellular systems, including through chemical and genetic manipulations, input-output methodologies, feedback approaches, and feed-forward approaches. We first discuss what happens in control-based approaches when we are not actively examining or manipulating cells. We then present potential methods to determine what the cell is doing during these times and to reverse-engineer the cellular system. Finally, we discuss how we can control the cell's extracellular and intracellular environments, both to probe the response of the cells using defined experimental engineering-based technologies and to anticipate what might be achieved by applying control-based approaches to affect cellular processes. Much work remains to apply simplified control models and develop new technologies to aid researchers in studying and utilizing cellular and molecular processes.

MeSH Terms (8)

Animals Cell Physiological Phenomena Cells Cytological Techniques Feedback, Physiological Humans Models, Biological Systems Biology

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