The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions.

Pirmohamed M, Aithal GP, Behr E, Daly A, Roden D
Clin Pharmacol Ther. 2011 89 (6): 784-5

PMID: 21593754 · DOI:10.1038/clpt.2011.30

The ability to predict the risk for serious drug-induced adverse reactions first requires a large patient database for characterization and validation of genetic markers. The Phenotype Standardization Project (PSP) was initiated to standardize phenotypic definitions, thereby facilitating much-needed recruitment without sacrificing the reliability of patient classification. Three phenotypes have been considered in this initial phase: drug-induced liver injury, drug-induced skin injury, and drug-induced torsade de pointes.

MeSH Terms (9)

Chemical and Drug Induced Liver Injury Consensus Development Conferences as Topic Drug-Related Side Effects and Adverse Reactions Humans Pharmaceutical Preparations Pharmacogenetics Phenotype Skin Diseases Torsades de Pointes

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