Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.

Pitts SL, Jablonksy MJ, Duca M, Dauzonne D, Monneret C, Arimondo PB, Anklin C, Graves DE, Osheroff N
Biochemistry. 2011 50 (22): 5058-66

PMID: 21548574 · PMCID: PMC3109987 · DOI:10.1021/bi200531q

MeSH Terms (11)

Antigens, Neoplasm Antineoplastic Agents, Phytogenic Cell Line, Tumor DNA DNA-Binding Proteins DNA Cleavage DNA Topoisomerases, Type II Drug Interactions Etoposide Humans Saccharomyces cerevisiae

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