Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents.

Kaushal N, Robson MJ, Vinnakota H, Narayanan S, Avery BA, McCurdy CR, Matsumoto RR
AAPS J. 2011 13 (3): 336-46

PMID: 21494909 · PMCID: PMC3160158 · DOI:10.1208/s12248-011-9274-9

MeSH Terms (20)

Administration, Oral Animals Benzoxazoles Cocaine Cytochrome P-450 Enzyme System Drug Interactions Half-Life Injections, Intraperitoneal Ligands Male Mice Motor Activity Piperazines Protein Binding Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Serotonin, 5-HT2 Receptors, sigma Seizures

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