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Impact of maternal immunization on influenza hospitalizations in infants.

Poehling KA, Szilagyi PG, Staat MA, Snively BM, Payne DC, Bridges CB, Chu SY, Light LS, Prill MM, Finelli L, Griffin MR, Edwards KM, New Vaccine Surveillance Network
Am J Obstet Gynecol. 2011 204 (6 Suppl 1): S141-8

PMID: 21492825 · PMCID: PMC3111909 · DOI:10.1016/j.ajog.2011.02.042

We sought to determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants <6 months old. Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 US counties from November through April during the 2002 through 2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses. Among 1510 hospitalized infants <6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted odds ratio, 0.53; 95% confidence interval, 0.32-0.88 and adjusted odds ratio, 0.52; 95% confidence interval, 0.30-0.91). Infants of vaccinated mothers were 45-48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.

Copyright © 2011 Mosby, Inc. All rights reserved.

MeSH Terms (13)

Female Hospitalization Humans Immunity, Maternally-Acquired Infant Influenza, Human Influenza Vaccines Population Surveillance Practice Guidelines as Topic Pregnancy Pregnancy Complications, Infectious Risk United States

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