Postpartum factors and natural fibroid regression.

Laughlin SK, Hartmann KE, Baird DD
Am J Obstet Gynecol. 2011 204 (6): 496.e1-6

PMID: 21492823 · PMCID: PMC3136622 · DOI:10.1016/j.ajog.2011.02.018

OBJECTIVE - Many fibroids regress with pregnancy or postpartum involution. We sought to identify factors that might inhibit or enhance this natural regression.

STUDY DESIGN - We used a prospective cohort of women with fibroids (n = 494) determined by ultrasound screening during the early first trimester identified from the Right from the Start study. Ultrasounds were repeated 3-6 months postpartum (n = 279). Logistic regression analyses were used to identify factors associated with fibroid regression (>50% reduction in volume).

RESULTS - Postpartum progestin users had significantly less fibroid regression (P = .01), whereas there was no association for combined estrogen-progestin use. Cesarean delivery and fever (hypothesized to inhibit regression) and breast feeding (hypothesized to enhance regression) were not associated with fibroid regression.

CONCLUSION - Progestin use in the postpartum period may limit regression of fibroids, consistent with prior literature on progesterone's role in fibroid development. Research into progestin-only treatments in critical reproductive periods is needed.

Copyright © 2011 Mosby, Inc. All rights reserved.

MeSH Terms (11)

Adult Breast Feeding Female Humans Leiomyoma Neoplasm Regression, Spontaneous Postpartum Period Pregnancy Pregnancy Complications, Neoplastic Prospective Studies Uterine Neoplasms

Connections (1)

This publication is referenced by other Labnodes entities: