Postpartum factors and natural fibroid regression.

Laughlin SK, Hartmann KE, Baird DD
Am J Obstet Gynecol. 2011 204 (6): 496.e1-6

PMID: 21492823 · PMCID: PMC3136622 · DOI:10.1016/j.ajog.2011.02.018

OBJECTIVE - Many fibroids regress with pregnancy or postpartum involution. We sought to identify factors that might inhibit or enhance this natural regression.

STUDY DESIGN - We used a prospective cohort of women with fibroids (n = 494) determined by ultrasound screening during the early first trimester identified from the Right from the Start study. Ultrasounds were repeated 3-6 months postpartum (n = 279). Logistic regression analyses were used to identify factors associated with fibroid regression (>50% reduction in volume).

RESULTS - Postpartum progestin users had significantly less fibroid regression (P = .01), whereas there was no association for combined estrogen-progestin use. Cesarean delivery and fever (hypothesized to inhibit regression) and breast feeding (hypothesized to enhance regression) were not associated with fibroid regression.

CONCLUSION - Progestin use in the postpartum period may limit regression of fibroids, consistent with prior literature on progesterone's role in fibroid development. Research into progestin-only treatments in critical reproductive periods is needed.

Copyright © 2011 Mosby, Inc. All rights reserved.

MeSH Terms (11)

Adult Breast Feeding Female Humans Leiomyoma Neoplasm Regression, Spontaneous Postpartum Period Pregnancy Pregnancy Complications, Neoplastic Prospective Studies Uterine Neoplasms

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