Significant 25-hydroxyvitamin D deficiency in child and adolescent survivors of acute lymphoblastic leukemia: treatment with chemotherapy compared with allogeneic stem cell transplant.

Simmons JH, Chow EJ, Koehler E, Esbenshade A, Smith LA, Sanders J, Friedman D
Pediatr Blood Cancer. 2011 56 (7): 1114-9

PMID: 21488156 · PMCID: PMC3135735 · DOI:10.1002/pbc.22949

BACKGROUND - 25-hydroxyvitamin D insufficiency is common in healthy children and adolescents. There have been limited studies of the 25-hydroxyvitamin D status of survivors of pediatric and adolescent acute lymphoblastic leukemia (ALL).

PROCEDURE - In a cohort of 78 ALL survivors (52 chemotherapy-treated and 26 HCT-treated), we determined the prevalence of, and host, treatment and environmental risk factors for 25-hydroxyvitamin D insufficiency and deficiency.

RESULTS - There were no differences in serum 25-hydroxyvitamin D levels between ALL survivors treated with conventional chemotherapy and those treated with HCT (median 26.0 vs 25.5 ng/ml). Fifty-three percent of pediatric ALL survivors were 25-hydroxyvitamin D insufficient (15-29 ng/dl), and 12% were deficient (<15 ng/dl). Younger age, higher reported dietary vitamin D intake, use of vitamin D supplementation, and increased ambient ultraviolet light were associated with higher serum 25-hydroxyvitamin D levels. There was not enough evidence to suggest treatment type, gender, race, years since diagnosis or BMI were associated with serum 25-hydroxyvitamin D levels. Only 27% of conventional chemotherapy-treated ALL survivors and 8% of HCT-treated ALL survivors met RDA for dietary vitamin D intake.

CONCLUSIONS - The prevalence of vitamin D deficiency and insufficiency in ALL survivors is similar to that of the general pediatric population in the United States, and there is no difference in serum 25-hydroxyvitamin D status between chemotherapy-treated and HCT-treated ALL survivors. ALL survivors rarely meet the RDA requirements for vitamin D. Further studies are needed to determine whether dietary and behavioral interventions can improve the vitamin D status of ALL survivors.

Copyright © 2010 Wiley-Liss, Inc.

MeSH Terms (24)

Adolescent Adult Antineoplastic Combined Chemotherapy Protocols Child Combined Modality Therapy Cross-Sectional Studies Cyclophosphamide Female Humans Male Neoplasm Recurrence, Local Precursor Cell Lymphoblastic Leukemia-Lymphoma Prednisone Prospective Studies Radiotherapy Dosage Salvage Therapy Stem Cell Transplantation Survival Rate Survivors Transplantation, Homologous Treatment Outcome Vitamin D Vitamin D Deficiency Young Adult

Connections (2)

This publication is referenced by other Labnodes entities: