Emerging structural themes in large RNA molecules.

Reiter NJ, Chan CW, Mondragón A
Curr Opin Struct Biol. 2011 21 (3): 319-26

PMID: 21474301 · PMCID: PMC3112254 · DOI:10.1016/j.sbi.2011.03.003

Extensive networks of tertiary interactions give rise to unique, highly organized domain architectures that characterize the three-dimensional structure of large RNA molecules. Formed by stacked layers of a near-planar arrangement of contiguous coaxial helices, large RNA molecules are relatively flat in overall shape. The functional core of these molecules is stabilized by a diverse set of tertiary interaction motifs that often bring together distant regions of conserved nucleotides. Although homologous RNAs from different organisms can be structurally diverse, they adopt a structurally conserved functional core that includes preassembled active and/or substrate binding sites. These findings broaden our understanding of RNA folding and tertiary structure stabilization, illustrating how large, complex RNAs assemble into unique structures to perform recognition and catalysis.

Copyright © 2011 Elsevier Ltd. All rights reserved.

MeSH Terms (6)

Adenosine Binding Sites Consensus Sequence Nucleic Acid Conformation Ribonucleoproteins RNA

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