Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.

Kennedy AL, Morton JP, Manoharan I, Nelson DM, Jamieson NB, Pawlikowski JS, McBryan T, Doyle B, McKay C, Oien KA, Enders GH, Zhang R, Sansom OJ, Adams PD
Mol Cell. 2011 42 (1): 36-49

PMID: 21474066 · PMCID: PMC3145340 · DOI:10.1016/j.molcel.2011.02.020

MeSH Terms (24)

Aged Animals Cell Line, Transformed Cell Proliferation Cellular Senescence Class I Phosphatidylinositol 3-Kinases Disease Models, Animal Enzyme Activation Female Gene Expression Regulation, Neoplastic Genes, ras Humans Male Mice Mice, Knockout Mice, Transgenic Middle Aged Mutation Neoplasms Pancreatic Neoplasms Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt PTEN Phosphohydrolase Signal Transduction

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