AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M
Cell Metab. 2011 13 (4): 376-388

PMID: 21459323 · PMCID: PMC3086578 · DOI:10.1016/j.cmet.2011.03.009

MeSH Terms (18)

AMP-Activated Protein Kinases Animals Atherosclerosis Benzopyrans Dietary Fats Disease Models, Animal Fatty Liver Humans Insulin Resistance Lipogenesis Male Metformin Mice Phosphorylation Receptors, LDL Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 Transcription, Genetic

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