Identification of neural targets for the treatment of psychiatric disorders: the role of functional neuroimaging.

Vago DR, Epstein J, Catenaccio E, Stern E
Neurosurg Clin N Am. 2011 22 (2): 279-305, x

PMID: 21435577 · DOI:10.1016/j.nec.2011.01.003

Neurosurgical treatment of psychiatric disorders has been influenced by evolving neurobiological models of symptom generation. The advent of functional neuroimaging and advances in the neurosciences have revolutionized understanding of the functional neuroanatomy of psychiatric disorders. This article reviews neuroimaging studies of depression from the last 3 decades and describes an emerging neurocircuitry model of mood disorders, focusing on critical circuits of cognition and emotion, particularly those networks involved in the regulation of evaluative, expressive and experiential aspects of emotion. The relevance of this model for neurotherapeutics is discussed, as well as the role of functional neuroimaging of psychiatric disorders.

Copyright © 2011 Elsevier Inc. All rights reserved.

MeSH Terms (16)

Brain Chemistry History, 18th Century History, 19th Century History, 20th Century History, Ancient Humans Mental Disorders Models, Neurological Nerve Net Nervous System Neurology Neuropsychiatry Neurosurgery Neurosurgical Procedures Phrenology Psychosurgery

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