FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.

Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller VA, Costa C, Hannon G, Sawyers CL
Nature. 2011 471 (7339): 523-6

PMID: 21430781 · PMCID: PMC3541675 · DOI:10.1038/nature09870

MeSH Terms (18)

Cell Line, Tumor Dose-Response Relationship, Drug Down-Regulation Drug Resistance, Neoplasm ErbB Receptors Erlotinib Hydrochloride fas Receptor Genes, erbB-1 Humans I-kappa B Proteins Lung Neoplasms Models, Biological Mutant Proteins Mutation NF-kappa B Quinazolines RNA Interference Signal Transduction

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