Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage.

Gentry AC, Pitts SL, Jablonsky MJ, Bailly C, Graves DE, Osheroff N
Biochemistry. 2011 50 (15): 3240-9

PMID: 21413765 · PMCID: PMC3086367 · DOI:10.1021/bi200094z

MeSH Terms (13)

Antigens, Neoplasm Antineoplastic Agents DNA DNA-Binding Proteins DNA Cleavage DNA Topoisomerases, Type II Drug Stability Etoposide Humans Podophyllotoxin Protein Binding Spermine Structure-Activity Relationship

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