Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).

Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA, Williams SP, Willson TM, Xu R, Zuercher WJ, Cai F, Ingraham HA
J Med Chem. 2011 54 (7): 2266-81

PMID: 21391689 · PMCID: PMC4151520 · DOI:10.1021/jm1014296

MeSH Terms (15)

Amino Acid Sequence Animals Crystallography, X-Ray HEK293 Cells Humans Ligands Mice Models, Molecular Molecular Sequence Data Protein Conformation Receptors, Cytoplasmic and Nuclear Sequence Homology, Amino Acid Small Molecule Libraries Steroidogenic Factor 1 Transcriptional Activation

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