Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase.

Garrett JT, Olivares MG, Rinehart C, Granja-Ingram ND, Sánchez V, Chakrabarty A, Dave B, Cook RS, Pao W, McKinely E, Manning HC, Chang J, Arteaga CL
Proc Natl Acad Sci U S A. 2011 108 (12): 5021-6

PMID: 21385943 · PMCID: PMC3064360 · DOI:10.1073/pnas.1016140108

MeSH Terms (19)

Animals Breast Neoplasms Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Lapatinib Mice Mice, Nude Neoplasm Transplantation Phosphatidylinositol 3-Kinases Protein Kinase Inhibitors Proto-Oncogene Proteins c-akt Quinazolines Receptor, ErbB-2 Receptor, ErbB-3 Transcription, Genetic Transplantation, Heterologous Up-Regulation

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