Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, Dunman PM
PLoS Pathog. 2011 7 (2): e1001287

PMID: 21347352 · PMCID: PMC3037362 · DOI:10.1371/journal.ppat.1001287

MeSH Terms (15)

Animals Anti-Infective Agents Female Hep G2 Cells Humans Mice Models, Biological Ribonuclease P RNA, Messenger RNA Processing, Post-Transcriptional Small Molecule Libraries Staphylococcal Infections Staphylococcus aureus Vancomycin Virulence

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