Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors.

Puzanov I, Lee W, Chen AP, Calcutt MW, Hachey DL, Vermeulen WL, Spanswick VJ, Liao CY, Hartley JA, Berlin JD, Rothenberg ML
Clin Cancer Res. 2011 17 (11): 3794-802

PMID: 21346148 · PMCID: PMC3107910 · DOI:10.1158/1078-0432.CCR-10-2056

MeSH Terms (15)

Adult Aged Aged, 80 and over Benzodiazepinones Dexamethasone Dyspnea Edema Fatigue Female Humans Male Maximum Tolerated Dose Middle Aged Neoplasms Pyrroles

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