Low kinetic hydrogen isotope effects in the dehydrogenation of 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (nifedipine) by cytochrome P-450 enzymes are consistent with an electron/proton/electron transfer mechanism.

Guengerich FP
Chem Res Toxicol. 1990 3 (1): 21-6

PMID: 2131820 · DOI:10.1021/tx00013a004

MeSH Terms (15)

Animals Cytochrome P-450 Enzyme System Deuterium Electron Transport Female Humans Hydrogenation Kinetics Male Microsomes, Liver Nifedipine Oxidation-Reduction Rats Rats, Inbred Strains Tritium

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