Telomere dysfunction induces metabolic and mitochondrial compromise.

Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA
Nature. 2011 470 (7334): 359-65

PMID: 21307849 · PMCID: PMC3741661 · DOI:10.1038/nature09787

MeSH Terms (19)

Adenosine Triphosphate Aging Animals Cardiomyopathies Cell Proliferation DNA, Mitochondrial Doxorubicin Gluconeogenesis Hematopoietic Stem Cells Liver Mice Mitochondria Myocardium Reactive Oxygen Species RNA Telomerase Telomere Transcription Factors Tumor Suppressor Protein p53

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