Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.

Pantel J, Williams SY, Mi D, Sebag J, Corbin JD, Weaver CD, Cone RD
Eur J Pharmacol. 2011 660 (1): 139-47

PMID: 21296065 · PMCID: PMC3175485 · DOI:10.1016/j.ejphar.2011.01.031

MeSH Terms (16)

Allosteric Regulation Cyclic AMP Drug Evaluation, Preclinical Furocoumarins HEK293 Cells High-Throughput Screening Assays Humans Luminescent Measurements Phosphodiesterase Inhibitors Pilot Projects Receptor, Melanocortin, Type 4 Reproducibility of Results Signal Transduction Structure-Activity Relationship Sulfonamides Time Factors

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