Non-invasive predictors of human cortical bone mechanical properties: T(2)-discriminated H NMR compared with high resolution X-ray.

Horch RA, Gochberg DF, Nyman JS, Does MD
PLoS One. 2011 6 (1): e16359

PMID: 21283693 · PMCID: PMC3025007 · DOI:10.1371/journal.pone.0016359

Recent advancements in magnetic resonance imaging (MRI) have enabled clinical imaging of human cortical bone, providing a potentially powerful new means for assessing bone health with molecular-scale sensitivities unavailable to conventional X-ray-based diagnostics. To this end, (1)H nuclear magnetic resonance (NMR) and high-resolution X-ray signals from human cortical bone samples were correlated with mechanical properties of bone. Results showed that (1)H NMR signals were better predictors of yield stress, peak stress, and pre-yield toughness than were the X-ray derived signals. These (1)H NMR signals can, in principle, be extracted from clinical MRI, thus offering the potential for improved clinical assessment of fracture risk.

MeSH Terms (10)

Biomechanical Phenomena Bone and Bones Fractures, Bone Humans Magnetic Resonance Spectroscopy Predictive Value of Tests Radiography Stress, Mechanical Tensile Strength X-Rays

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