Genetic modifiers of neurological disease.

Kearney JA
Curr Opin Genet Dev. 2011 21 (3): 349-53

PMID: 21251811 · PMCID: PMC3105121 · DOI:10.1016/j.gde.2010.12.007

Genetic modifiers make an important contribution to neurological disease phenotypes. Significant progress has been made by studying genetic modifiers in model organisms. The ability to study complex genetic interactions in model systems contributes to our understanding of the genetic factors that influence neurological disease. This will lead to the development of novel therapeutic strategies and personalized treatment based on genetic risk.

Copyright © 2010 Elsevier Ltd. All rights reserved.

MeSH Terms (12)

Animals Carrier Proteins Charcot-Marie-Tooth Disease Disease Models, Animal Humans Huntington Disease Mice Nervous System Diseases Phenotype Rett Syndrome RNA Splicing Factors Spinocerebellar Ataxias

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