Angiotensin II: breathtaking in the renal medulla.

Haase VH
Kidney Int. 2011 79 (3): 269-71

PMID: 21228800 · PMCID: PMC3621768 · DOI:10.1038/ki.2010.434

Angiotensin II (Ang II) is a major contributor to the progression of renal fibrosis. Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normoxic conditions, thus placing the HIF oxygen-sensing pathway into the center of an Ang II-induced profibrotic signaling cascade.

MeSH Terms (18)

Actins Angiotensin II Animals Basic Helix-Loop-Helix Transcription Factors Cell Transdifferentiation Collagen Type I Collagen Type III Fibrosis Humans Hydrogen Peroxide Hypoxia-Inducible Factor 1, alpha Subunit Kidney Medulla Procollagen-Proline Dioxygenase Proliferating Cell Nuclear Antigen Rats Tissue Inhibitor of Metalloproteinase-1 Up-Regulation Vimentin

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