Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe.

Reid PR, Bridges TM, Sheffler DJ, Cho HP, Lewis LM, Days E, Daniels JS, Jones CK, Niswender CM, Weaver CD, Conn PJ, Lindsley CW, Wood MR
Bioorg Med Chem Lett. 2011 21 (9): 2697-701

PMID: 21194936 · PMCID: PMC3082000 · DOI:10.1016/j.bmcl.2010.12.015

MeSH Terms (11)

Allosteric Regulation Brain Cells, Cultured Drug Discovery Indoles Inhibitory Concentration 50 Molecular Probes Molecular Structure Receptor, Muscarinic M1 Structure-Activity Relationship Sulfones

Connections (3)

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