TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling.

Johnson RW, Nguyen MP, Padalecki SS, Grubbs BG, Merkel AR, Oyajobi BO, Matrisian LM, Mundy GR, Sterling JA
Cancer Res. 2011 71 (3): 822-31

PMID: 21189326 · PMCID: PMC3077118 · DOI:10.1158/0008-5472.CAN-10-2993

MeSH Terms (16)

Animals Bone Neoplasms Breast Neoplasms Female Hedgehog Proteins Humans Kruppel-Like Transcription Factors Mice Mice, Nude Nuclear Proteins Parathyroid Hormone-Related Protein Recombinant Proteins Signal Transduction Transforming Growth Factor beta Veratrum Alkaloids Zinc Finger Protein Gli2

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