Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.

Lamb JP, Engers DW, Niswender CM, Rodriguez AL, Venable DF, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2011 21 (9): 2711-4

PMID: 21183344 · PMCID: PMC3179182 · DOI:10.1016/j.bmcl.2010.11.119

MeSH Terms (10)

Allosteric Regulation Drug Discovery Molecular Structure Oxadiazoles Piperidines Protein Binding Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Stereoisomerism Structure-Activity Relationship

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