Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats.

Dhanya RP, Sidique S, Sheffler DJ, Nickols HH, Herath A, Yang L, Dahl R, Ardecky R, Semenova S, Markou A, Conn PJ, Cosford ND
J Med Chem. 2011 54 (1): 342-53

PMID: 21155570 · PMCID: PMC3071440 · DOI:10.1021/jm1012165

MeSH Terms (17)

Administration, Oral Allosteric Regulation Animals Benzothiazoles Biological Availability Brain Chlorobenzoates Cocaine Cocaine-Related Disorders Drug Design HEK293 Cells Humans Rats Receptors, Metabotropic Glutamate Self Administration Structure-Activity Relationship Tissue Distribution

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