The development of physiologic responsiveness to muscarinic stimulation in embryonic chick heart. Relationship to increased levels of pertussis toxin substrates.

Barnett JV, Shamah SM, Galper JB
Ann N Y Acad Sci. 1990 588: 145-54

PMID: 2113368 · DOI:10.1111/j.1749-6632.1990.tb13205.x

Studies of the development of parasympathetic responsiveness in embryonic chick hearts have demonstrated that between days 2.5 and 10 in ovo the ability of muscarinic agonists to inhibit adenylate cyclase activity increases 10-fold in parallel with a 2.7-fold increase in the level of alpha i and alpha o. Thus, muscarinic inhibition of adenylate cyclase increases in parallel with an increase in alpha o and alpha i. These data suggest that changes in levels of guanine nucleotide regulatory proteins control, at least in part, the appearance of a parasympathetic response in the heart during embryonic development of the chick.

MeSH Terms (15)

Adenylate Cyclase Toxin Adenylyl Cyclases Animals Chick Embryo GTP-Binding Proteins Heart Immunoblotting Isoproterenol Myocardium Organ Culture Techniques Pertussis Toxin Poly(ADP-ribose) Polymerases Receptors, Muscarinic Substrate Specificity Virulence Factors, Bordetella

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