Death due to asthma in two adolescents with sickle cell disease.

Field JJ, Horst J, Strunk RC, White FV, DeBaun MR
Pediatr Blood Cancer. 2011 56 (3): 454-7

PMID: 21113938 · DOI:10.1002/pbc.22891

In one prospective cohort study, a diagnosis of asthma was associated with an increased risk of mortality in individuals with sickle cell anemia or HbSS. However, a direct relationship between death and asthma exacerbation could not be documented. This report examines two adolescents with sickle cell disease (SCD) who died during worsening symptoms consistent with asthma. Autopsies in both individuals demonstrated pulmonary airway smooth muscle hyperplasia, basement membrane thickening, and eosinophilia, consistent with bronchial asthma. Individuals with SCD and asthma warrant ongoing education, treatment, and surveillance for life-threatening complications of asthma.

© 2010 Wiley-Liss, Inc.

MeSH Terms (11)

Adolescent Adult Anemia, Sickle Cell Asthma Bronchial Hyperreactivity Fatal Outcome Humans Male Prognosis Survival Rate Young Adult

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