Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.

Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS
Nature. 2010 468 (7326): 973-7

PMID: 21107323 · PMCID: PMC3143360 · DOI:10.1038/nature09626

MeSH Terms (20)

Base Sequence Cell Line, Tumor Drug Resistance, Neoplasm Enzyme Activation Gene Expression Regulation, Neoplastic Genes, ras Humans Indoles MAP Kinase Signaling System Melanoma Mitogen-Activated Protein Kinase Kinases Mutation Oligonucleotide Array Sequence Analysis Protein Kinase Inhibitors Proto-Oncogene Proteins B-raf Receptor, Platelet-Derived Growth Factor beta Receptor Protein-Tyrosine Kinases Sulfonamides Up-Regulation Vemurafenib

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