Obesity, age, and oxidative stress in middle-aged and older women.

Dorjgochoo T, Gao YT, Chow WH, Shu XO, Yang G, Cai Q, Rothman N, Cai H, Li H, Deng X, Shrubsole MJ, Murff H, Milne G, Zheng W, Dai Q
Antioxid Redox Signal. 2011 14 (12): 2453-60

PMID: 21043829 · PMCID: PMC3096497 · DOI:10.1089/ars.2010.3337

Recent evidence suggests that urinary F(2)-isoprostanes (F(2)-IsoPs) are more accurate markers of oxidative stress than other available biomarkers. Most previous studies used unmetabolized F(2)-IsoPs as a biomarker. Few previous studies measured 15-F(2t)-IsoP-M, a metabolite of one of the most common F(2)-IsoPs, 15-F(2t)-IsoP. Unlike 15-F(2t)-IsoP, 15-F(2t)-IsoP-M is not subject to autoxidation and renal production. To our knowledge, no study has compared the associations of age and body mass index (BMI) with F(2)-IsoPs to those with 15-F(2t)-IsoP-M. Urinary levels of F(2)-IsoPs and 15-F(2t)-IsoP-M were measured using gas chromatography-mass spectrometry for 845 healthy women aged 40-70 years. Both F(2)-IsoPs and 15-F(2t)-IsoP-M were elevated among smokers. The level of 15-F(2t)-IsoP-M increased with age, particularly after menopause, and with BMI. In contrast, F(2)-IsoPs decreased with age, regardless of menopausal status, and was not related to BMI. The association of 15-F(2t)-IsoP-M with age or menopausal status did not differ by BMI category, and the association with BMI was also independent of age or menopausal status. 15-F(2t)-IsoP-M appears to be a valuable biomarker of oxidative stress in age- and obesity-related diseases.

MeSH Terms (15)

Adult Aged Age Factors Asian Continental Ancestry Group Biomarkers Body Mass Index Cross-Sectional Studies F2-Isoprostanes Female Humans Menopause Middle Aged Obesity Oxidative Stress Women's Health

Connections (7)

This publication is referenced by other Labnodes entities: