Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations.

Bruner-Tran KL, Osteen KG
Reprod Toxicol. 2011 31 (3): 344-50

PMID: 20955784 · PMCID: PMC3044210 · DOI:10.1016/j.reprotox.2010.10.003

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a ubiquitous environmental contaminant and known endocrine disruptor. Since humans and animals are most sensitive to toxicant exposure during development, we previously developed a mouse model of in utero TCDD exposure in order to examine the impact of this toxicant on adult reproductive function. Our initial in utero toxicant-exposure study revealed a dose-dependent reduction in uterine sensitivity to progesterone; however, we did not previously explore establishment or maintenance of pregnancy. Thus, in the current study, we examined pregnancy outcomes in adult C57BL/6 mice with a history of developmental TCDD exposure. Herein we demonstrate reduced fertility and an increased incidence of premature birth (PTB) in F1 mice exposed in utero to TCDD as well as in three subsequent generations. Finally, our studies revealed that mice with a history of developmental TCDD exposure exhibit an increased sensitivity to inflammation which further negatively impacted gestation length in all generations examined.

Copyright © 2010 Elsevier Inc. All rights reserved.

MeSH Terms (16)

Animals Disease Models, Animal Dose-Response Relationship, Drug Environmental Pollutants Epigenesis, Genetic Female Fertility Male Maternal Exposure Mice Mice, Inbred C57BL Polychlorinated Dibenzodioxins Pregnancy Premature Birth Prenatal Exposure Delayed Effects Uterus

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