Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.

Kang DW, Kim YS, Lim KS, Kim MS, Pearce LV, Pavlyukovets VA, Tao AK, Lang-Kuhs KA, Blumberg PM, Lee J
Bioorg Med Chem. 2010 18 (22): 8092-105

PMID: 20937561 · PMCID: PMC3420354 · DOI:10.1016/j.bmc.2010.09.001

MeSH Terms (12)

Acetamides Animals Benzamides Capsaicin CHO Cells Cricetinae Cricetulus Halogenation Rats Structure-Activity Relationship Thiourea TRPV Cation Channels

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