Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.

Rodriguez AL, Grier MD, Jones CK, Herman EJ, Kane AS, Smith RL, Williams R, Zhou Y, Marlo JE, Days EL, Blatt TN, Jadhav S, Menon UN, Vinson PN, Rook JM, Stauffer SR, Niswender CM, Lindsley CW, Weaver CD, Conn PJ
Mol Pharmacol. 2010 78 (6): 1105-23

PMID: 20923853 · PMCID: PMC2993468 · DOI:10.1124/mol.110.067207

MeSH Terms (17)

Allosteric Regulation Animals Anti-Anxiety Agents Antipsychotic Agents Cells, Cultured Cricetinae Dose-Response Relationship, Drug HEK293 Cells Humans Male Mice Motor Activity Psychomotor Agitation Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate

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